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Home > Oncologist Home > US Oncology Research > US Oncology Research Trials US Oncology Research Trials US Oncology Research provides novel therapies to patients in the community setting and allows participatation in landmark clinical trials. Use the search function below to view all open trials currently being conducted by US Oncology Research. View All... Brain Cancer Breast Cancer Colon Cancer Endometrial Cancer Esophageal Cancer Head and Neck Cancer Hematologic ITP Leukemia Lung Cancer Lymphomas Melanoma Myelodysplastic Syndrome Myelomas Ovarian Cancer Pancreatic Cancer Prostate Cancer Renal Cancer Sarcoma Skin Cancer Solid Tumors Supportive Care Thromboses/Coagulation CLINICAL TRIAL SEARCH RESULTS Trial Number: NCT01227954 Cancer Type: Brain Cancer A Phase II Trial of Hippocampal Avoidance During Whole Brain Radiotherapy for Brain Metastases Read More Trial Number: NCT00696072 Cancer Type: Breast Cancer (CA180-185) Randomized Phase II Trial of Letrozole with or without Dasatinib as First and Second-Line Treatment for Hormone Receptor-Positive, HER2-Negative Post-Menopausal Breast Cancer that is Unresectable, Locally Recurrent or Metastatic Read More Trial Number: NCT00103181 Cancer Type: Breast Cancer A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer (RTOG 0413) Read More Trial Number: NCT00968968 Cancer Type: Breast Cancer A Randomized, Phase III, Open-label Study of Lapatinib plus Trastuzumab versus Trastuzumab as Continued HER2 Suppression Therapy after Completion of First- or Second-line Trastuzumab plus Chemotherapy in Subjects with HER2-positive Metastatic Breast Cancer (LPT112515) Read More Trial Number: NCT00769379 Cancer Type: Breast Cancer A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation and Radiation Alone for Women with Her2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy Read More Trial Number: NCT01269346 Cancer Type: Breast Cancer Protocol Number E7389-A001-208: A Phase 2, Multicenter, Single-Arm Study of Eribulin Mesylate With Trastuzumab as First-Line Therapy for Locally Recurrent or Metastatic Human Epidermal Growth Factor Receptor Two (HER2)Positive Breast Cancer Read More Trial Number: NCT01007890 Cancer Type: Breast Cancer Prediction of Response to Neoadjuvant Chemotherapy in Women with Operable Breast Cancer (PT-304) Read More Trial Number: NCT01421472 Cancer Type: Breast Cancer MM-121-02-02-07:A Randomized, Phase 2 Trial of Preoperative MM-121 with Paclitaxel in HER2-negative Breast Cancer Read More Trial Number: NCT01355770 Cancer Type: Breast Cancer Randomized, Open-Label Study of Abiraterone Acetate (JNJ 212082) Plus Prednisone With or Without Exemestane in Postmenopausal Women With ER+ Metastatic Breast Cancer Progressing After Letrozole or Anastrozole Therapy (212082BCA2001) Read More Trial Number: NCT01492101 Cancer Type: Breast Cancer 11-PIR-11: The BEACON Study (Breast Cancer Outcomes With Nktr-102): A Phase 3 Open-Label, Randomized, Multicenter Study Of NKTR-102 Versus Treatment Of Physician’s Choice (TPC) In Patients With Locally Recurrent Or Metastatic Breast Cancer Previously Treated With An Anthracycline, A Taxane, And Capecitabine Read More Trial Number: NCT01349322 Cancer Type: Breast Cancer A Phase III Trial Of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost For Early-Stage Breast Cancer (RTOG 1005) Read More Trial Number: NCT01183780 Cancer Type: Colon Cancer Protocol I4T-MC-JVBB (also known as IMCL CP12 0920) A Randomized, Double-Blind, Multicenter Phase 3 Study of Irinotecan, Folinic Acid, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab or Placebo in Patients With Metastatic Colorectal Carcinoma Progressive During or Following First-Line Combination Therapy With Bevacizumab, Oxaliplatin, and a Fluoropyrimidine Read More Trial Number: NCT00807768 Cancer Type: Endometrial Cancer GOG 0249- A Phase III Trial of Pelvic Radiation Therapy versus Vaginal Cuff Brachytherapy followed by PACLITAXEL/CARBOPLATIN Chemotherapy in patients with High-Risk, early stage Endometrial Carcinoma Read More Trial Number: NCT00655876 Cancer Type: Esophageal Cancer A Phase III Trial Evaluating The Addition Of Cetuximab To Paclitaxel, Cisplatin, And Radiation For Patients With Esophageal Cancer Who Are Treated Without Surgery (RTOG 0436) Read More Trial Number: NCT00956007 Cancer Type: Head and Neck Cancer A PHASE III STUDY OF POSTOPERATIVE RADIATION THERAPY (IMRT) +/- CETUXIMAB FOR LOCALLY-ADVANCED RESECTED HEAD AND NECK CANCER (RTOG 0920) Read More Trial Number: NCT01204099 Cancer Type: Head and Neck Cancer Phase 1/2 Study of PX-866 and docetaxel in patients with solid tumors (PX-866-002) Read More Trial Number: NCT01088048 Cancer Type: Hematologic (CAL 101-07) A Phase I Study to Investigate the Safety and Clinical Activity of CAL-101 in Combination with Chemotherapeutic Agents and Anti-CD20 mAb in Patients with Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia Read More Trial Number: NCT00547066 Cancer Type: ITP IM-T-hA20-07: A Phase I/II Study of Immunotherapy with Humanized Anti-CD20 Antibody, IMMU-106 (hA20), in Adult Patients with Chronic Immune Thrombocytopenia Purpura Read More Trial Number: NCT01461538 Cancer Type: Leukemia SGN35-013: A Phase 2, open-label, single-arm study of brentuximab vedotin in patients with CD30-positive nonlymphomatous malignancies Read More Trial Number: NCT01244750 Cancer Type: Leukemia CA180330: Studying Interventions for Managing Patients with Chronic Myeloid Leukemia in Chronic Phase: The 5-Year Prospective Cohort Study (SIMPLICITY) Read More Trial Number: NCT00686959 Cancer Type: Lung Cancer (H3E-MC-JMIG): Phase 3 Study of Pemetrexed, Cisplatin,and Radiotherapy Followed by Consolidation Pemetrexed versus Etoposide, Cisplatin, and Radiotherapy Followed by Consolidation Cytotoxic Chemotherapy of Choice in Patients with Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer Other than Predominantly Squamous Cell Histology Read More Trial Number: NCT00858364 Cancer Type: Lung Cancer Amgen Protocol 20070782: A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long-term Safety and Efficacy of Darbepoetin Alfa Administered at 500 µg Once-Every-3-Weeks in Anemic Subjects With Advanced Stage Non-small Cell Lung Cancer Receiving Multi-cycle Chemotherapy Read More Trial Number: NCT01160744 Cancer Type: Lung Cancer Protocol IMCL CP12-0917: An Open-label, Multicenter, Randomized, Phase 2 Study of a Recombinant Human Anti-VEGFR-2 Monoclonal Antibody, IMC-1121B in Combination with Platinum-based Chemotherapy versus Platinum-based Chemotherapy Alone as First-line Treatment of Patients with Recurrent or Advanced Non-small Cell Lung Cancer (NSCLC) Read More Trial Number: NCT01168973 Cancer Type: Lung Cancer Protocol I4T-MC-JVBA (also known as IMCL CP12-1027) A Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancer Following Disease Progression after One Prior Platinum- Based Therapy Read More Trial Number: NCT01204099 Cancer Type: Lung Cancer Phase 1/2 Study of PX-866 and docetaxel in patients with solid tumors (PX-866-002) Read More Trial Number: NCT01297491 Cancer Type: Lung Cancer An open label two-stage study of orally administered BKM120 in patients with metastatic non-small cell lung cancer with activated PI3K pathway (CBKM120D2201) Read More Trial Number: NCT01362400 Cancer Type: Lung Cancer A Phase 2, Double-Blind, Placebo-Controlled Study of IPI-504 and Docetaxel in Previously Treated Patients with Stage IIIB or IV Non-Small Cell Lung Cancer (IPI-504-14) Read More Trial Number: NCT01362296 Cancer Type: Lung Cancer (MEK114653) A Phase II, Open-label, Multicenter, Randomized Study to Assess the Efficacy and Safety of GSK1120212 Compared with Docetaxel in 2nd Line Subjects with Targeted Mutations (KRAS, NRAS, BRAF, MEK1) in Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC Stage IV). Read More Trial Number: NCT00998192 Cancer Type: Lung Cancer A Phase 2 Study of Intravenous Administration of REOLYSIN® (Reovirus Type 3 Dearing) in Combination with Paclitaxel and Carboplatin in Patients with Squamous Cell Carcinoma of the Lung (REO 021) Read More Trial Number: NCT01529112 Cancer Type: Lung Cancer E7080-703: A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Oral E7080 in Addition to Best Supportive Care (BSC) versus BSC Alone in Patients with Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Who Have Failed at Least Two Systemic Anticancer Regimens Read More Trial Number: NCT01218516 Cancer Type: Lung Cancer A Randomized, Double-Blind, Placebo-Controlled, Study of the Safety and Efficacy of Farletuzumab in Combination with a Platinum Containing Doublet in Chemotherapy-Naive Subjects with Stage IV Adenocarcinoma of the Lung (MORAb-003-009) Read More Trial Number: NCT00931918 Cancer Type: Lymphomas Protocol C05013 - An Open-Label, Randomized, Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Patients with Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Read More Trial Number: NCT01109069 Cancer Type: Lymphomas A Long-term Safety Study of Bruton’s Tyrosine Kinase (Btk) Inhibitor PCI-32765 in B cell Lymphoma and Chronic Lymphocytic Leukemia (PCYC-1103-CA) Read More Trial Number: NCT01321541 Cancer Type: Lymphomas PIX306: A Randomized Multicenter Study Comparing Pixantrone + Rituximab with Gemcitabine + Rituximab in Patients with Aggressive B-cell Non-Hodgkin Lymphoma Who Have Relapsed after Therapy with CHOP-R or an Equivalent Regimen and are Ineligible for Stem Cell Transplant Read More Trial Number: NCT01294579 Cancer Type: Lymphomas OFB114612: Phase II Open-Label Study of Ofatumumab and Bendamustine Followed by Maintenance Ofatumumab for Indolent B-cell Non-Hodgkin’s Lymphoma (B-NHL) Which Has Relapsed after Rituximab Therapy Read More Trial Number: NCT01421667 Cancer Type: Lymphomas SGN35-012: A phase 2 study of brentuximab vedotin in relapsed or refractory CD30-positive non-Hodgkin lymphoma (NHL) Read More Trial Number: NCT01136967 Cancer Type: Melanoma (E7080-G000-206): An Open-Label, 2-Cohort, Multicenter, Phase 2 Study of E7080 in Previously Treated Subjects With Unresectable Stage III or Stage IV Melanoma Read More Trial Number: NCT00940602 Cancer Type: Myelodysplastic Syndrome A multi-center, randomized, double-blind, placebo-controlled clinical trial of deferasirox in patients with myelodysplastic syndromes (low/int-1 risk) and transfusional iron overload (TELESTO) Protocol Number: CICL670A2302 Read More Trial Number: NCT01002248 Cancer Type: Myelomas A Phase III Randomized Study to Assess the Efficacy and Safety of Perifosine Added to the Combination of Bortezomib and Dexamethasone in Multiple Myeloma Patients Previously Treated with Bortezomib (Perifosine 339) Read More Trial Number: NCT01461538 Cancer Type: Myelomas SGN35-013: A Phase 2, open-label, single-arm study of brentuximab vedotin in patients with CD30-positive nonlymphomatous malignancies Read More Trial Number: NCT01454297 Cancer Type: Myelomas A prospective, longitudinal, observational study in newly diagnosed multiple myeloma (MM) patients to assess the relationship between patient outcomes, treatment regimens and molecular profiles (MMRF–11–001) Read More Trial Number: NCT01493505 Cancer Type: Ovarian Cancer 20101129(TRINOVA-3): A Phase 3 Randomized, Double-blind, Placebo-controlled, Multicenter Study of AMG 386 With Paclitaxel and Carboplatin as First-line Treatment of Subjects With FIGO Stage III-IV Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancers Read More Trial Number: NCT01231347 Cancer Type: Pancreatic Cancer 20060540: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled, Trial of AMG 479 or Placebo in Combination with Gemcitabine as First-line Therapy for Metastatic Adenocarcinoma of the Pancreas Read More Trial Number: NCT01013649 Cancer Type: Pancreatic Cancer A Phase III Trial Evaluating both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma (RTOG 0848) Read More Trial Number: NCT00567580 Cancer Type: Prostate Cancer A Phase III Trial Of Short Term Androgen Deprivation With Pelvic Lymph Node Or Prostate Bed Only Radiotherapy (Spport) In Prostate Cancer Patients With A Rising Psa After Radical Prostatectomy (RTOG 0534) Read More Trial Number: NCT00936390 Cancer Type: Prostate Cancer A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer RTOG 0815 Read More Trial Number: NCT01322490 Cancer Type: Prostate Cancer BNIT-PRV-301: A Randomized, Double-blind, Phase 3 Efficacy Trial of PROSTVAC-V/F +\- GM-CSF in Men With Asymptomatic or Minimally Symptomatic Metastatic, Castrate-Resistant Prostate Cancer Read More Trial Number: NCT01234311 Cancer Type: Prostate Cancer A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of Tasquinimod in Men with Metastatic Castrate-Resistant Prostate Cancer (10TASQ10) Read More Trial Number: NCT01306890 Cancer Type: Prostate Cancer P10-3: A Registry of Sipuleucel-T Therapy in Men with Advanced Prostate Cancer Read More Trial Number: NCT01235962 Cancer Type: Renal Cancer A randomized, double-blind, placebo-controlled phase III study to evaluate the efficacy and safety of pazopanib as adjuvant therapy for subjects with localized or locally advanced RCC following nephrectomy (VEG113387) Read More Trial Number: NCT01223027 Cancer Type: Renal Cancer (CTKI258A2302): An open-label, randomized, multi-center, Phase III study to compare the safety and efficacy of TKI258 versus sorafenib in patients with metastatic renal cell carcinoma after failure of anti-angiogenic (VEGF-targeted and mTOR inhibitor) therapies Read More Trial Number: NCT01441414 Cancer Type: Renal Cancer B1131004:Phase II Trial of PF-04856884 (CVX-060), A Selective Angiopoietin-2 (ANG-2) Inhibitor in Combination with AG-013736 (Axitinib) in Patients with Previously Treated Metastatic Renal Cell Carcinoma Read More Trial Number: NCT01168791 Cancer Type: Sarcoma IPM3001: A Phase III multicenter, international, randomized, double-blind, placebo-controlled study of doxorubicin plus palifosfamide-tris vs. doxorubicin plus placebo in patients with front-line metastatic soft tissue sarcoma Read More Trial Number: NCT01327053 Cancer Type: Skin Cancer A phase II, randomized double-blind study of efficacy and safety of two dose levels of LDE225 in patients with locally advanced or metastatic basal cell carcinoma (CLDE225A2201) Read More Trial Number: NCT01192165 Cancer Type: Solid Tumors (MEK113486): A Open-Label, Phase I/Ib Dose Escalation Study to Assess the Safety and Tolerability of GSK1120212 in Combination with Docetaxel, Erlotinib, Pemetrexed, Pemetrexed + Carboplatin, Pemetrexed + Cisplatin, or nab-Paclitaxel in Subjects with Advanced Solid Tumors Read More Trial Number: NCT01304784 Cancer Type: Solid Tumors A Phase 1 and Pharmacologic Study of MM-111 in Combination with Multiple Treatment Regimens in Patients with Advanced HER2 Positive Solid Tumors (MM-111-01-01-03) Read More Trial Number: NCT01461538 Cancer Type: Solid Tumors SGN35-013: A Phase 2, open-label, single-arm study of brentuximab vedotin in patients with CD30-positive nonlymphomatous malignancies Read More Trial Number: NCT01375842 Cancer Type: Solid Tumors Protocol PCD4989g: A Phase I, Open Label, Dose Escalation Study of the Safety and Pharmacokinetics of MPDL3280A Administered Intravenously As a Single Agent to Patients With Locally Advanced or Metastatic Solid Tumors Read More Trial Number: NCT00858364 Cancer Type: Supportive Care Amgen Protocol 20070782: A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long-term Safety and Efficacy of Darbepoetin Alfa Administered at 500 µg Once-Every-3-Weeks in Anemic Subjects With Advanced Stage Non-small Cell Lung Cancer Receiving Multi-cycle Chemotherapy Read More Trial Number: NCT00986154 Cancer Type: Thromboses/Coagulation Protocol DU-176b-D-U305: A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel-Group, Multicenter, Multi-National Study for the Evaluation of Efficacy and Safety of (LMW) Heparin/Edoxaban Versus (LMW) Heparin/Warfarin in Subjects with Symptomatic Deep-Vein Thrombosis and/or Pulmonary Embolism Read More

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