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Ewings Family of Tumors - Childhood
Overview
Ewings sarcoma family of tumors is a group of tumors that form from a certain kind of cell in bone or soft tissue.

Ewings tumors usually occur in teenagers and are more common in boys and Caucasians.

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Source: National Cancer Institute

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Tumor Types
This family of tumors includes the following:
 
Ewings tumor of bone. This type of tumor is found in the bones of the legs, arms, chest, trunk, back, or head. There are three types of Ewings tumor of bone:
• Classic Ewings sarcoma.
• Primitive neuroectodermal tumor (PNET).
• Askin tumor (PNET of the chest wall).
Extraosseous Ewings sarcoma (tumor growing in tissue other than bone). This type of soft tissue tumor is found in the trunk, arms, legs, head, and neck.

In some patients, the tumor may have spread by the time it is diagnosed.

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Source: National Cancer Institute

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Symptoms
These and other symptoms may be caused by Ewings sarcoma family of tumors. Other conditions may cause the same symptoms. Consult a doctor if any of the following problems occur:
 
• Pain and/or swelling, most commonly in the arms, legs, chest, back, or pelvis (area between the hips).
• A lump (which may feel warm) in the arms, legs, chest, or pelvis.
• Fever for no known reason.
• A bone that breaks for no known reason.
 

Source: National Cancer Institute

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Treatment
Different types of treatments are available for children with Ewings sarcoma family of tumors. Some treatments are standard (the currently used treatment, often referred to as “standard of care”), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.

Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment.

Three types of standard treatment are used:

Chemotherapy
Chemotherapy is part of the treatment for all patients with Ewings tumors. It is usually given first, to shrink the tumor before treatment with surgery or radiation therapy. It may also be given to kill any tumor cells that have spread to other parts of the body.

Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). Combination chemotherapy is treatment using more than one anticancer drug. The way the chemotherapy is given depends on the type of the cancer being treated and whether it is found at the place it first formed only or whether it has spread to other parts of the body.

Surgery
Surgery is usually done to remove cancer that is left after chemotherapy or radiation therapy. When possible, the entire tumor is removed by surgery. Tissue and bone that are removed may be replaced with a graft using tissue and bone taken from another part of the patient's body or a donor, or with an implant such as artificial bone.

Radiation therapy
Radiation therapy may be used to shrink the tumor before surgery so less tissue needs to be removed. It may also be used to kill tumor cells that are left after surgery or chemotherapy. Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. The way the radiation therapy is given depends on the type of the cancer being treated and whether it is found at the place it first formed only or whether it has spread to other parts of the body.

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Source: National Cancer Institute

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